Your First Semaglutide or Tirzepatide Injection: What to Expect
Nervous about your first weekly injection? Here's what to expect, where the shot goes, how to store your medication and what to do if you miss a dose.
Published 2026-11-13 by Avere Beauty
If you've never given yourself a shot, the first one can feel like a big deal. Here's the good news: almost everyone says it was much easier than they expected. Here's what to know before your first dose.
Written by the Avere Beauty weight loss team · November 2026
We'll walk you through it
At Avere, you pick up your medication at the office, and your provider shows you how to measure and give your dose. You're welcome to give your first injection with us there. Always follow the instructions on your prescription label, since doses and steps can differ.
Where the shot goes
Semaglutide and tirzepatide go just under the skin (a subcutaneous injection), not into muscle. Common spots are:
- Your stomach area, at least two inches away from your belly button
- The front of your thigh
- The back of your upper arm (easier if someone helps you)
Use a slightly different spot each week to keep skin comfortable.
A simple routine
- Pick your day. Choose the same day each week and set a phone reminder.
- Wash your hands and gather your supplies.
- Clean the spot with an alcohol swab and let it dry.
- Check your dose against your instructions before you inject.
- Inject slowly, then hold for a few seconds before removing the needle.
- Dispose of needles safely in a sharps container, never loose in the trash.
Storing your medication
Store your medication exactly as your label says. Most GLP-1 medications are kept in the refrigerator. Don't freeze it, don't leave it in a hot car, and keep it out of direct sunlight. Traveling? Ask us how to pack it.
What you might notice the first week
- Less appetite, sometimes within a day or two
- Mild nausea or a full feeling, especially after big or rich meals
- A little redness at the injection spot, which usually fades quickly
Starting at a low dose keeps side effects milder while your body adjusts. Here's how to ease common side effects.
If you miss a dose
Don't take two doses to catch up. What to do depends on your medication and how many days it's been, so check your instructions or message your provider. Our team offers 24/7 support, so you're never guessing.
Frequently asked questions
Does a semaglutide or tirzepatide injection hurt?
Most people say it feels like a quick pinch. The needle is very small and the shot goes just under the skin, not into muscle.
Where do you inject semaglutide or tirzepatide?
These medications are injected under the skin of the stomach area (at least two inches from the belly button), the front of the thigh, or the back of the upper arm. Rotate where you inject each week.
What if I miss my weekly dose?
What to do depends on the medication and how long it's been. Don't double up. Follow your prescription instructions or contact your provider, who will tell you whether to take it now or wait for your next scheduled day.
How should I store my medication?
Store it exactly as your prescription label and pharmacy instructions say. Most GLP-1 medications are kept in the refrigerator and should never be frozen or left in a hot car.
This article is general education, not medical advice. Weight loss medication is prescribed only after a provider reviews your health history, and results vary from person to person.
Ready to talk it through? Book a $50 weight loss consultation, call 412-952-7592, or read how our program works.
Avere Beauty · Pittsburgh medical spa founded by Alyssa Luciano, RN · 4 locations: Lawrenceville (3453 Butler St), Murrysville (5100 Old William Penn Hwy, Export), Mars/Cranberry (179 Scharberry Ln), Blawnox/Fox Chapel (307 Freeport Rd) · 412-952-7592 · averebeauty.com